15 June 2023
New publication KKGT section
The KKGT section has a new publication: “Busulfan Interlaboratory Proficiency Testing Program Revealed Worldwide Errors in Drug Quantitation and Dose Recommendations”.
his article provides an overview of the results of the international proficiency test Busulfan. Busulfan is a drug used in the treatment of leukemia prior to a stem cell transplant. Because the drug is very toxic, and the required dosage differs for each patient, busulfan concentrations are measured in the blood of the patients. The dosages then adjusted on the basis of that concentration. What makes the measurement even more difficult is that busulfan decomposes quickly, so technically this analysis also presents the necessary challenges. In this article, the authors show that major improvements are still needed worldwide in the analysis and dose advice of busulfan, and that participation in a proficiency test can help to achieve this.